SEC61A1 — SEC61 translocon subunit alpha 1
SEC61A1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SEC61A1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | UPR / ER Stress Protein processing & ER | CALR, CANX, CTSB, CTTN, GRN, HDLBP, HSP90B1, HSPA5 +10 more | View in SCUBA |
| Gamma-delta T cells | ER Protein Translocation Protein processing & ER | ATG2A, BEST1, CLSTN1, CTDSP2, GALC, GSE1, HAPSTR1, HOOK2 +12 more | |
| Macrophages | Protein Biogenesis Housekeeping | ATP6V0D1, B3GAT3, BUD23, C11orf58, CHD4, CNPY2, DAZAP1, DDX46 +23 more | View in SCUBA |
| Mucosal-associated invariant T cell | Chromatin Remodeling DNA/chromatin regulation | ANP32E, ARHGAP30, CANX, DCTN1, EPRS1, FLII, HK1, JAK3 +9 more |
About the gene
| Chromosome | 3: 128051641-128071705 |
|---|---|
| Predicted location | Membrane |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters |
| Molecular function | Chaperone |
| Biological process | Protein transport, Translocation, Transport |
Function
Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post-translational transport of small presecretory proteins. The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex. The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER. Controls the passive efflux of calcium ions from the ER lumen to the cytosol through SEC61 channel, contributing to the maintenance of cellular calcium homeostasis. Plays a critical role in nephrogenesis, specifically at pronephros stage (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.