SIVA1 — SIVA1 apoptosis inducing factor
SIVA1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SIVA1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Cell Cycle G1/S Cell cycle | CARHSP1, CBX5, CENPM, DNMT1, GMNN, HMGB2, HMGN2, MND1 +8 more | View in SCUBA |
| CD8⁺ T cells | S-phase Progression Cell cycle | CENPH, CENPM, CENPU, DNAJC9, DSCC1, EBP, NCAPH2, PCLAF +5 more | View in SCUBA |
| Endothelial | DNA Replication Cell cycle | CENPX, DNMT1, ICMT, IDH2, MCM3, MCM4, MCM5, MCM6 +11 more | View in SCUBA |
| Gamma-delta T cells | G1/S Entry Cell cycle | CDKN2A, CKS2, CMC2, H2AZ1, H2AZ2, HMGB2, IFI27L1, KPNA2 +15 more | |
| Macrophages | Mitotic Spindle Assembly Cell cycle | ACTL6A, AKR7A2, ANP32E, BOLA3, BUB3, CCDC167, CENPW, CENPX +34 more | View in SCUBA |
| Smooth muscle cells | OXPHOS Complex I Mitochondrial & OxPhos | CLTB, COPS6, ETFB, IAH1, MRPS21, NDUFA2, NDUFB10, NDUFC2 +3 more | View in SCUBA |
About the gene
| Synonyms | CD27BP, SIVA, Siva-1, Siva-2 |
|---|---|
| Chromosome | 14: 104753147-104768494 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Apoptosis, Host-virus interaction |
Function
Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.