P2RX4 — Purinergic receptor P2X 4
P2RX4 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
P2RX4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Actomyosin Contractility Cytoskeletal | BCL7C, BLCAP, C20orf204, CMBL, CTDSPL, DDB2, FLRT2, ITM2C +11 more | View in SCUBA |
| Gamma-delta T cells | DNA Repair Housekeeping Housekeeping | ANAPC16, CCDC85B, CDIP1, CKLF, COTL1, DNAJC4, ECH1, ERCC1 +10 more | |
| Macrophages | Osmotic Stress Response Stress | ANKRD28, BZW1, CD109, CXCL8, CYB5R4, CYTIP, DUSP4, EMP3 +25 more | View in SCUBA |
About the gene
| Synonyms | P2X4 |
|---|---|
| Chromosome | 12: 121210065-121234106 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | FDA approved drug targets, Predicted membrane proteins, Transporters |
| Molecular function | Ion channel, Ligand-gated ion channel, Receptor |
| Biological process | Ion transport, Transport |
Function
ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium. CTP, but not GTP or UTP, functions as a weak affinity agonist for P2RX4 (By similarity). Activated by extracellularly released ATP, it plays multiple role in immunity and central nervous system physiology. Plays a key role in initial steps of T-cell activation and Ca(2+) microdomain formation (By similarity). Also participates in basal T-cell activity without TCR/CD3 stimulation (By similarity). Promotes the differentiation and activation of Th17 cells via expression of retinoic acid-related orphan receptor C/RORC. Upon activation, drives microglia motility via the PI3K/Akt pathway (By similarity). Could also function as an ATP-gated cation channel of lysosomal membranes (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.