TPGS2 — Tubulin polyglutamylase complex subunit 2
TPGS2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TPGS2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | DNA Damage Repair DNA/chromatin regulation | APPL1, GPAA1, HMGB1, HNRNPM, HNRNPR, NAP1L4, NCL, PRDX3 +7 more | View in SCUBA |
| Innate lymphoid cells | ILC1 Lymphocyte Signaling Immune regulation | CDIPT, CNPY3, DBNL, ENG, IL16, LIMD2, LSM2, MAPKAPK3 +11 more | View in SCUBA |
| Macrophages | Replication Chromatin Assembly Cell cycle | ANP32B, CBX3, CDK4, COPS3, DEK, DNMT1, EMC8, EXOSC8 +22 more | View in SCUBA |
About the gene
| Synonyms | C18orf10, DKFZP586M1523, HsT3006, PGs2 |
|---|---|
| Chromosome | 18: 36777647-36829216 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Subunit of the tubulin polyglutamylase complex (TPGC). The complex mediates cilia and flagella polyglutamylation which is essential for their biogenesis and motility
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.