Long-gene intronic signal
Gene co-expression module in Enterocytes
| Category | Technical artifact |
|---|---|
| Genes | 14 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 12 of 14 genes have a known function matching the annotation |
Why this annotation
Long genes (ASCC3, SAMD12, VPS13C, RALGAPA2, TANC1, CASK, MECOM, MID1) point to a nuclear/unspliced transcript signature. LGR4 and KCNQ1 hint at a crypt progenitor identity, but the scattered functions of the remaining genes make this most consistent with a long-gene/intronic-read technical program.
Genes
ASCC3, CASK, KCNQ1, LGR4, MAP3K5, MECOM, MID1, PPP1R9A, RALGAPA2, SAMD12, SRGAP1, TANC1, TMTC2, VPS13C
Most correlated modules
- Epithelial polarity cytoskeleton · correlation 0.89
- Transit-amplifying progenitor · correlation 0.88
- Focal adhesion actin · correlation 0.86
- Epithelial NF-kB response · correlation 0.72
- IFN-gamma immunoproteasome · correlation 0.72
- Crypt CFTR secretion · correlation 0.70
- ER chaperone/UPR · correlation 0.69
- Serotonergic receptor signaling · correlation 0.63
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.