MEAF6 — MYST/Esa1 associated factor 6
MEAF6 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MEAF6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Innate lymphoid cells | Mixed Proteostasis Metabolism Metabolism | ADRM1, ANXA11, ATP6V0B, CISD2, COX17, DNAJC8, DR1, EIF3I +18 more | View in SCUBA |
| Macrophages | Glycogen Metabolism Housekeeping | ARL2BP, BTF3L4, CAPN1, CD47, CRLS1, DCTD, DSTN, GLOD4 +24 more | View in SCUBA |
| Mucosal-associated invariant T cell | Cellular Housekeeping Housekeeping | AKR7A2, ANP32A, ANXA5, AP1M1, APEX1, APOBEC3C, CDC26, DBNL +17 more |
About the gene
| Synonyms | C1orf149, CENP-28, Eaf6, FLJ11730, NY-SAR-91 |
|---|---|
| Chromosome | 1: 37489993-37514766 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, Predicted intracellular proteins |
| Molecular function | Activator, Chromatin regulator |
| Biological process | Transcription, Transcription regulation |
Function
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.