PTP4A1 — Protein tyrosine phosphatase 4A1
PTP4A1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PTP4A1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Colonocyte terminal differentiation Epithelial development | CCDC186, CEACAM1, CMPK1, FHL2, GCNT3, HKDC1, IFNGR1, LRRFIP1 +2 more | View in SCUBA |
| Macrophages | Glycogen Metabolism Housekeeping | ARL2BP, BTF3L4, CAPN1, CD47, CRLS1, DCTD, DSTN, GLOD4 +24 more | View in SCUBA |
| Smooth muscle cells | Proliferative Biosynthesis Housekeeping | ARF5, BUB3, CBX5, DCTN3, DUT, HMGN2, IDH2, KRTCAP2 +7 more | View in SCUBA |
About the gene
| Synonyms | PRL-1, PRL1, PTPCAAX1 |
|---|---|
| Chromosome | 6: 63521746-63583588 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Developmental protein, Hydrolase, Protein phosphatase |
| Biological process | Cell cycle |
Function
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.