Tissue-destructive Macrophage
Gene co-expression module in Monocytes
| Category | Lysosomal & pahgocytosis |
|---|---|
| Genes | 16 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 16 genes have a known function matching the annotation |
Why this annotation
ENG (endoglin) is a TGF-β co-receptor expressed on activated macrophages and endothelial cells, marking tissue-remodeling macrophages. ACP5 (TRAP/tartrate-resistant acid phosphatase) is a hallmark of osteoclasts and inflammatory tissue-destructive macrophages. FABP5 marks inflammatory/lipid-loaded macrophages. MMP19 is a matrix metalloprotease involved in tissue invasion and remodeling. BCAT1 (branched-chain aminotransferase 1) is upregulated in inflammatory macrophages. SPHK1 (sphingosine kinase 1) drives pro-inflammatory sphingosine-1-phosphate signaling. IL10 (anti-inflammatory cytokine) may represent a counter-regulatory signal. MCOLN1 (mucolipin-1) is lysosomal. LDLRAD4 participates in TGF-β signaling. Low expression/detection but strongly inflammation-associated in IBD. This module resembles a tissue-destructive, osteoclast-like inflammatory macrophage program active in IBD mucosa.
Genes
ACP5, ANKH, BCAT1, ENG, FABP5, ID3, IL10, KIFC3, LDLRAD4, MCOLN1, MMP19, PAPSS2, SDS, SH3PXD2B, SPHK1, TMEM51
Most correlated modules
- Monocyte Tissue Infiltration · correlation 0.71
- Monocyte Lipid Handling · correlation 0.70
- Monocyte Immune Tolerance · correlation 0.69
- ER Stress Response · correlation 0.68
- Non-classical Monocyte State · correlation 0.63
- Inflammatory Cell Death · correlation 0.61
- M2 Macrophage Polarization · correlation 0.59
- Complement C1q Macrophage · correlation 0.58
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.