PLGRKT — Plasminogen receptor with a C-terminal lysine
PLGRKT belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PLGRKT's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Myeloid Contamination Cell contamination | BASP1, C7, CARMIL1, CCL23, CH25H, CSRP2, CTSC, DENND2D +20 more | View in SCUBA |
| Hematopoietic progenitor cells | ER Protein Folding Housekeeping | ASRGL1, CALR, CD63, CHPT1, EMP3, GLUL, HSPA5, IDH2 +13 more |
About the gene
| Synonyms | AD025, C9orf46, FLJ14688, MDS030, Plg-RKT |
|---|---|
| Chromosome | 9: 5357971-5437925 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins |
| Biological process | Chemotaxis, Inflammatory response, Plasminogen activation |
Function
Receptor for plasminogen. Regulates urokinase plasminogen activator-dependent and stimulates tissue-type plasminogen activator- dependent cell surface plasminogen activation. Proposed to be part of a local catecholaminergic cell plasminogen activation system that regulates neuroendocrine prohormone processing. Involved in regulation of inflammatory response; regulates monocyte chemotactic migration and matrix metalloproteinase activation, such as of MMP2 and MMP9
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.