WHRN — Whirlin
WHRN belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
WHRN's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | LAYN+ tissue Treg Immune regulation | BEX3, CADM1, CHRNA6, EPHX2, FLVCR2, GNG8, IKZF4, LAPTM4B +7 more | View in SCUBA |
| Gamma-delta T cells | Chromatin Epigenetic Regulation DNA/chromatin regulation | ADNP2, ARID4B, CEBPZ, ELL2, ENSG00000285976, ETF1, HIPK1, JMJD1C +17 more | |
| Innate lymphoid cells | NK Cytotoxic Effector Cytotoxicity | ACAA2, APIP, B4GALNT1, CAMK4, CCL5, CCNG2, CD247, CD3E +17 more | View in SCUBA |
| Mucosal-associated invariant T cell | BMP/TGF-β Inhibitory Immune regulation | ACHE, BUD31, FAM43A, ID1, LMNA, N4BP3, PRR7, RGS16 +2 more |
About the gene
| Synonyms | CIP98, DFNB31, PDZD7B, USH2D |
|---|---|
| Chromosome | 9: 114402080-114505473 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins |
| Biological process | Hearing |
Function
Involved in hearing and vision as member of the USH2 complex. Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear. Involved in the maintenance of the hair bundle ankle region, which connects stereocilia in cochlear hair cells of the inner ear. In retina photoreceptors, required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.