PDE4A — Phosphodiesterase 4A

PDE4A belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

PDE4A's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	NFkB/MAPK activation BCR/AP1/NFKb pathway	BIRC3, CCDC107, CD72, CHI3L2, CLEC2B, DENND4A, LRRFIP1, MAP3K8 +7 more	View in SCUBA
CD4⁺ T cells	Effector activation NFkB TCR/AP1/NFKb pathway	ADAM19, AHR, ARFGAP3, ATF5, BHLHE40, CGAS, DUSP5, ETF1 +23 more	View in SCUBA
Gamma-delta T cells	cAMP Lipid Signaling Immune regulation	ABL1, AKIRIN2, B9D2, CEMIP2, CHPT1, CTDP1, DKK3, GGA2 +15 more
Innate lymphoid cells	NK ILC Tissue Homing Homing & TEM	ADGRE5, AKAP13, AREG, ARL4C, ATP1B3, B3GNT7, BTG1, CCDC107 +25 more	View in SCUBA
Macrophages	Autophagy Vesicle Trafficking Lysosomal & pahgocytosis	ADNP2, AGO2, AP1G1, ARFGAP3, ATG2A, BANP, CHD1, CHD2 +26 more	View in SCUBA
Monocytes	TREM1 Inflammatory Signaling Innate immunity	AGO2, AKAP12, ATP2B1, B3GNT5, BTG1, C17orf107, CHRNE, ERRFI1 +6 more	View in SCUBA

About the gene

Synonyms	DPDE2
Chromosome	19: 10416773-10469630
Predicted location	Intracellular
Essential gene	No
Protein class	Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins
Molecular function	Hydrolase

Function

Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. Efficiently hydrolyzes cAMP. Efficiently hydrolyzes cAMP. Efficiently hydrolyzes cAMP. The phosphodiesterase activity is not affected by calcium, calmodulin or cyclic GMP (cGMP) levels. Does not hydrolyze cGMP. Efficiently hydrolyzes cAMP. Efficiently hydrolyzes cAMP. Efficiently hydrolyzes cAMP

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.