Pol II Transcription Regulation
Gene co-expression module in CD4⁺ T cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 37 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 37 genes have a known function matching the annotation |
Why this annotation
Mixed module with chromatin/transcription regulators (BRD2, HEXIM1, POLR2A, PPP1R10, CBX4, SRSF2, ERF), cell-cycle genes (UBE2S, CKS2, CDKN1C, GADD45B), and tubulins (TUBB4B, TUBA1B). Hubs BRD2/HEXIM1/POLR2A point to RNA Pol II transcriptional regulation/P-TEFb control. FOXJ1 is somewhat atypical. Core coherence; dominant theme is transcriptional/chromatin regulation coupled to proliferation.
Genes
ABHD5, BAIAP2, BRD2, CBX4, CDKN1C, CITED2, CKS2, EHD1, EIF4A1, ERF, FAM53C, FOXJ1, GADD45B, HEXIM1, IER5L, INTS6, IQCN, JUNB, MEPCE, MIDN, MKNK2, NCKAP5L, NUFIP2, ODC1, POLR2A, PPP1R10, SERTAD1, SIRT1, SOCS1, SRSF2, TUBA1B, TUBB2A, TUBB4B, UAP1, UBE2S, YME1L1, ZNF296
Most correlated modules
- Integrated Stress Response · correlation 0.85
- Immediate Early AP-1 · correlation 0.81
- Unfolded Protein Response · correlation 0.80
- NF-kB activation · correlation 0.69
- Hypoxia metabolic stress · correlation 0.68
- T cell quiescence · correlation 0.64
- Heat Shock Response · correlation 0.57
- NF-kB Feedback Response · correlation 0.54
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.