PARVB — Parvin beta
PARVB belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PARVB's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Mitochondrial OxPhos Mitochondrial & OxPhos | ARPC1B, ATP5MF, AURKAIP1, NDUFB2, NDUFS6, PFN1, POLR2E, SERF2 +3 more | View in SCUBA |
| Gamma-delta T cells | Tissue Resident CD103+ Tissue residence | ADRB1, BCAS4, BLMH, CCNJL, CD160, CD96, CLIC5, CLNK +28 more | |
| Hematopoietic progenitor cells | Hematopoietic Progenitor Identity Stemness | CD38, DAD1, HSH2D, HYAL3, ITGAE, KIT, MBOAT2, MTHFD2 +2 more |
About the gene
| Synonyms | CGI-56 |
|---|---|
| Chromosome | 22: 43999211-44172939 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Actin-binding |
| Biological process | Cell adhesion |
Function
Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.