NK ILC Tissue Homing
Gene co-expression module in Innate lymphoid cells
| Category | Homing & TEM |
|---|---|
| Genes | 34 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 34 genes have a known function matching the annotation |
Why this annotation
Strong coherence. CXCR4 (strong) is the canonical chemokine receptor mediating homing to CXCL12-rich niches. RGS1 (strong) is a G-protein signaling regulator that promotes tissue retention by desensitizing CXCR4 signaling — a known gut residency marker. SATB1 (weak) is a chromatin organizer critical for NK/T cell identity. STAT4 (weak) mediates IL-12/IL-18 signaling in NK/ILC1 cells. SRGN (core) is serglycin, a proteoglycan stored in cytotoxic granules. PFKFB3 (strong) drives glycolysis during activation. CTNNB1 (Wnt/β-catenin) and AKAP13 (signaling scaffold) add regulatory context. The CXCR4+RGS1+SATB1+STAT4+SRGN combination reflects NK/ILC identity with tissue homing and cytotoxic granule components. Lower delta_inflammation than neighbors suggests a more constitutive identity program.
Genes
ADGRE5, AKAP13, AREG, ARL4C, ATP1B3, B3GNT7, BTG1, CCDC107, CCR6, CTNNB1, CXCR4, DCTN6, FAM177A1, HECTD1, HIPK1, HOXA5, LDLRAD4, LPIN1, MED30, P2RY10, PDE4A, PFKFB3, PIK3R1, PLEKHA2, RGS1, RORA, SAMSN1, SATB1, SDCBP, SMCHD1, SPART, SRGN, STAT4, TNS3
Most correlated modules
- NR4A Activation Response · correlation 0.81
- Prostaglandin-AP1 Response · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.