PRMT9 — Protein arginine methyltransferase 9
PRMT9 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PRMT9's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Plasma cell secretory B cell maturation | AARSD1, ATP1B3, BCAS2, CHMP1B, DNAJB9, ELL2, ETV3, IDI1 +9 more | View in SCUBA |
| CD4⁺ T cells | Immediate early activation TCR/AP1/NFKb pathway | ALG13, AREG, BCAS2, C9orf72, CXCR4, FAM222A, HIP1R, NR4A2 +18 more | View in SCUBA |
| Innate lymphoid cells | NR4A Activation Response activation | ALG13, ARL4A, BCAS2, CASP3, CHMP1B, CREM, DDX24, DLL1 +16 more | View in SCUBA |
| Macrophages | NF-κB Activation Inflammatory | BCL3, BLOC1S6, CD83, CFLAR, CHMP1B, CNOT2, CSRNP1, CYLD +33 more | View in SCUBA |
| Natural Killer cells | NRF2 Stress Response Stress | C1orf56, CNOT6L, CWC25, DDX18, FAM133B, JOSD1, KMT2E, NFE2L2 +2 more | View in SCUBA |
About the gene
| Synonyms | FLJ46629, PRMT10 |
|---|---|
| Chromosome | 4: 147637785-147684163 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Methyltransferase, Transferase |
Function
Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA). Specifically mediates the symmetrical dimethylation of SF3B2. Involved in the regulation of alternative splicing of pre-mRNA
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.