TMIGD2 — Transmembrane and immunoglobulin domain containing 2
TMIGD2 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TMIGD2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Cytotoxic effector Cytotoxicity | ADAP1, ALOX5AP, AOAH, CD244, CMIP, CPNE7, CRTAM, DAPK2 +15 more | View in SCUBA |
| CD8⁺ T cells | Tc17 program Tc17 program | ABI3, ABRACL, CAPG, CCDC85B, FKBP11, GPR34, IL17A, KLRB1 +4 more | View in SCUBA |
| Gamma-delta T cells | Tissue Resident CD103+ Tissue residence | ADRB1, BCAS4, BLMH, CCNJL, CD160, CD96, CLIC5, CLNK +28 more | |
| Innate lymphoid cells | ILC1 Actin Motility Cytoskeleton & motility | ACAP1, ARHGDIB, CORO1A, DGCR6L, EVL, GPSM3, HEXA, LCK +14 more | View in SCUBA |
| Mucosal-associated invariant T cell | Tc17 / MAIT17 Tc17 program | AHR, BAIAP2, CA10, CCR9, GFPT2, HIC1, IL17A, IL2 +5 more | |
| Natural Killer cells | NK Checkpoint Receptors Immune regulation | CD7, CD96, CRACR2B, DAPK2, ECH1, ECI2, ISYNA1, KIR2DL4 +5 more | View in SCUBA |
About the gene
| Synonyms | CD28H, IGPR-1, MGC23244 |
|---|---|
| Chromosome | 19: 4292227-4302431 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins |
Function
Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.