MYOF — Myoferlin
MYOF belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MYOF's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | IL-13/STAT6 Signaling Inflammation | ABLIM1, ARL2BP, ASRGL1, ATP8B1, BMP1, BMPR2, CLIP1, CMIP +18 more | View in SCUBA |
| Macrophages | SPP1 Tissue Remodeling ECM remodeling | BST1, CD52, CHI3L1, CHIT1, CSF1, FBP1, FGR, FN1 +19 more | View in SCUBA |
| Monocytes | Type I Interferon Response Antiviral | HEG1, IFITM1, IRF9, LY6E, OAS1, PLAAT4, PSMB10, WARS1 | View in SCUBA |
About the gene
| Synonyms | FER1L3, KIAA1207 |
|---|---|
| Chromosome | 10: 93306429-93482334 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
Function
Calcium/phospholipid-binding protein that plays a role in the plasmalemma repair mechanism of endothelial cells that permits rapid resealing of membranes disrupted by mechanical stress. Involved in endocytic recycling. Implicated in VEGF signal transduction by regulating the levels of the receptor KDR (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.