Early response genes
Gene co-expression module in Macrophages
| Category | Inflammatory |
|---|---|
| Genes | 48 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 20 of 48 genes have a known function matching the annotation |
Why this annotation
The module combines two co-activated programs: (1) heat shock chaperones (HSPD1, DNAJB1, HSPH1, HSPA1A, HSPA1B, DNAJA4, HSP90AB1, BAG3) and (2) AP-1/immediate early genes (FOS, FOSB, JUNB, JUN, ATF3, IER2, NR4A1, NR4A2, BTG2). This combination is a hallmark of dissociation-induced stress in single-cell experiments, where mechanical/enzymatic tissue dissociation triggers both proteotoxic stress (HSPs) and immediate early gene induction (AP-1). DUSP1 and ZFP36 are also stress-responsive. The uniform expression across subsets and weak coherence further support a technical artifact rather than a specific in vivo activation state.
Genes
ATF3, BAG3, BTG2, CGAS, DNAJA1, DNAJA4, DNAJB1, DNAJB4, DUSP1, EGR1, EGR2, EIF4A3, FOS, FOSB, GADD45B, HSP90AA1, HSP90AB1, HSPA1A, HSPA1B, HSPA6, HSPA8, HSPD1, HSPE1, HSPH1, IER2, IRF2BP2, JUN, JUNB, JUND, KLF4, KLF6, LITAF, MAFB, NFKBIA, NFKBIZ, NR4A1, NR4A2, OAT, PMAIP1, PNRC1, POLR1F, SERPINH1, SGK1, TNFAIP3, TNFSF9, YBX3, ZFP36, ZFP36L1
Most correlated modules
- Anti-inflammatory Response · correlation 0.94
- NF-κB Activation · correlation 0.91
- JAK-STAT Cytokine Response · correlation 0.83
- NF-κB Effector Response · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.